METHOD FOR PREPARING SULFATED DERIVATIVES OF ARABINOGALACTAN POSSESSING ANTICOAGULATING AND HYPOLIPIDEMIC ACTIVITY Russian patent published in 2008 - IPC C07H3/02 C08B37/00 

FIELD: chemical-pharmaceutical industry.

SUBSTANCE: invention relates to a method for synthesis of arabinogalactan-base sulfated biopolymers wherein arabinogalactan is the main polysaccharide from Siberian larch. Invention describes a method for preparing sulfated derivatives of arabinogalactan that involves interaction of arabinogalactant in dimethylsulfoxide medium in the ratio 1:3 with a sulfating agent representing complex SO₃ - dimethylformamide in the concentration of SO₃ ≥18%. The process is carried out at continuous stirring, at temperature 20^°C for 30 min followed by isolation of product both in acid and saline forms. The substitution degree of biopolymer macromolecule is 8.1-12.65% as measured for the quantitative content of sulfur. Synthesized sulfated derivatives of arabinogalactan retain the structural organization, water-solubility and membranotropicity of natural polysaccharide, and elicit high physiological (anticoagulating and hypolipidemic) activity also.

EFFECT: improved method of synthesis.

2 cl, 3 dwg, 3 ex