FIELD: biotechnology, medicine, proteins.
SUBSTANCE: invention proposes chimeric polypeptide that comprises cell-specific targeting moiety and granzyme. Polypeptide prepared by recombinant way is used for inducing apoptosis in target-cell. Invention provides carrying out the effective treatment of malignant neoplasms by directed lysis of tumor cells. Invention can be used in therapy of hyperproliferative disorders.
EFFECT: valuable medicinal properties of agents.
24 cl, 3 tbl, 35 dwg, 41 ex
| Title | Year | Author | Number |
|---|---|---|---|
| POLYPEPTIDES OF DIRECTED ACTION | 2006 |
|
RU2393874C2 |
| MODIFIED PROTEINS, CONSTRUCTED TOXINS AND METHODS FOR PRODUCTION THEREOF | 2002 |
|
RU2305684C2 |
| APOPTOSIS DETECTION TECHNIQUES AND REAGENTS | 2007 |
|
RU2450273C2 |
| APPLICATION OF FUSED TIMP-GPI CONSTRUCT AND METHOD OF TREATING SKIN INJURES FOR CICATRISATION PREVENTION OR INHIBITION | 2006 |
|
RU2428479C2 |
| PEPTIDES OF DIRECTED ACTION OF VEGFR-1/NRP-1 | 2008 |
|
RU2488592C2 |
| PRODUCTION OF BIOLOGICALLY ACTIVE PROTEINS | 2007 |
|
RU2441911C2 |
| PREPARATIONS, CONTAINING ANTIBODIES AGAINST Fas LIGAND, FOR TREATING PEMPHIGUS | 2009 |
|
RU2556818C2 |
| METHODS OF APPLYING OF APO-2L-RECEPTORS AGONISTS AND NK-CELLS ACTIVATORS | 2005 |
|
RU2395294C2 |
| ANTIBODIES | 2005 |
|
RU2482131C2 |
| ANTIBODIES TO OX-2/CD200 AND THEIR APPLICATION | 2007 |
|
RU2520088C2 |
