SUBSTITUTED PYRROLO[4,3-b]INDOLES, COMBINATORY AND FOCUSED LIBRARY, PHARMACEUTICAL COMPOSITION, METHODS FOR THEIR PREPARING AND USING Russian patent published in 2008 - IPC C07D487/04 A61K31/407 A61P9/10 A61P25/08 A61P25/14 A61P25/28 A61P11/06 A61P17/02 A61P17/06 A61P17/00 A61P37/08 A61P39/06 C07D207/00 C07D209/00 

FIELD: organic chemistry, medicine, neurology, pharmacy.

SUBSTANCE: invention relates to novel hydrogenated pyrrolo[4,3-b]indoles of the general formula (1): , their racemates, optical isomers, geometric isomers, pharmaceutically acceptable salts and/or hydrates that can be used, for example, in treatment and prophylaxis of different neurodegenerative diseases, such as Alzheimer's syndrome. In the general formula (1): a dotted line with accompanying unbroken line represents ordinary or double bond; R¹ and R² represent independently of one another substitutes of amino group chosen from hydrogen atom, possibly substituted (C₁-C₆)-alkyl substituted possibly with aryl, possibly substituted phenyl, possibly substituted carbonylamino or thiocarbonylamino group, substituted acyl, possibly substituted aryl sulfonate wherein substituted in indicated R¹ and R² are chosen from (C₁-C₆)-alkyl, halogen atoms, nitro, carboxy, alkoxy group, aryl; R¹ _n represents one or some similar or different substituted of cyclic system chosen from hydrogen atom, alkyl, aryl, cyano group, halogen atom, 5-6-membered nitrogen-containing heteroaryl. Also, invention relates to methods for synthesis of these compounds, pharmaceutical compositions and their using, and to using compounds in libraries with their using.

EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions, improved methods of synthesis.

20 cl, 2 tbl, 12 ex