SUBSTITUTED AZEPINO[4,3-b]INDOLES, PHARMACEUTICAL COMPOSITION, METHOD FOR THEIR PREPARING AND USING Russian patent published in 2008 - IPC C07D487/04 A61K31/55 A61P9/10 A61P25/08 A61P25/14 A61P25/28 A61P11/06 A61P17/02 A61P17/04 A61P17/00 A61P37/08 A61P39/06 C07D223/00 C07D209/00 

FIELD: organic chemistry, chemical technology, medicine, pharmacy.

SUBSTANCE: invention relates to novel hydrogenated azepino[4,3-b]indoles of the general formula (1): , their racemates, optical isomers, geometric isomers and their pharmaceutically acceptable salts and/or hydrates. In the general formula (1) a dotted line with accompanying unbroken line represents a simple or double bond; R¹ and R² represent independently of one another substitutes of amino-group chosen from hydrogen atom, possibly substituted (C₁-C₈)-alkyl possibly substituted with aryl, 5-6-membered azaheterocyclyl, (C₁-C₈)-alkoxycarbonyl, possibly substituted phenyl, possibly substituted carbonylamino- or thiocarbonylamino-group, substituted acyl, (C₁-C₈)-alkylsulfonyl, possibly substituted arylsulfonyl and wherein substitutes in indicated R¹ and R² are chosen independently from (C₁-C₈)-alkyl, halogen atoms, nitro-, carboxy-, alkoxy-group, aryl; Rⁱ _n represents one or some similar or different substitutes of cyclic system chosen from hydrogen atom, (C₁-C₈)-alkyl, (C₆-C₁₀)-aryl, halogen atom, 5-6-membered azaheterocyclyl. Also, invention relates to methods for synthesis of these compounds, their using and pharmaceutical composition and libraries of compounds. Synthesized compounds possess neuroprotective, cognitive-stimulating and anti-histaminic properties and can be used in treatment of different neurological disorders, allergic and autoimmune diseases, for example, for memory improvement.

EFFECT: valuable medicinal and biological properties of compounds and pharmaceutical composition, improved method of synthesis.

25 cl, 2 tbl, 12 ex