FIELD: organic chemistry, medicine, biochemistry pharmacy.
SUBSTANCE: invention relates to using the known 2-phenyl-substituted imidazotriazinone of the formula (I): 
(vardenafil) possessing improved properties as compared with other known inhibitors of phosphodiesterase-5 (PDE-5), such as sildenafil and tadalafil. Proposed compound is used for preparing drugs used in treatment of cardiac insufficiency.
EFFECT: valuable medicinal and biochemical properties of compound.
1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING SULFAMIDE-SUBSTITUTED IMIDAZOTRIAZINONES | 2001 |
|
RU2299211C2 |
| HERBICIDE AGENT BASED ON ARYLSULFONYLAMINOCARBONYLTRIAZOLINONES | 1997 |
|
RU2240691C2 |
| PDE INHIBITORS AND THEIR COMBINATIONS FOR TREATMENT OF UROLOGIC DISORDERS | 2006 |
|
RU2435588C2 |
| DERIVATIVES OF 8-PHENYL-6,9=DIHYDRO[1,24]TRIAZOLO[3,4-i]PURINE-5-ONE, METHODS FOR THEIR PREPARING, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND TREATMENT METHOD | 2000 |
|
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| IMIDAZOTRIAZINONE COMPOUNDS | 2011 |
|
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| SUBSTITUTED SULPHONAMIDE DERIVATIVES | 2009 |
|
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| PYRROLTRIAZINE KINASE INHIBITORS | 2000 |
|
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| NEW ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE AND PHOSPHODIESTERASE INHIBITORS WITH DUAL ACTION MECHANISM AND THEIR APPLICATION | 2018 |
|
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| NEW PHARMACEUTICAL COMPOSITIONS FOR SEXUAL DISORDERS | 2005 |
|
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| DERIVATIVES OF IMIDAZOPYRIDINES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING | 1995 |
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