FIELD: chemistry.
SUBSTANCE: compounds are the inhibitors of phosphodiesterase 9 (PDE9). In formula
X is selected from a bond; R1 is selected in an independent way from the group, consisting of (C1-C6)alkyl; R2 is selected in an independent way from the group, consisting of (C1-C6)alkyl, (C3-C10)cycloalkyl, heterocycloalkyl, containing 6 atoms in a ring, where 1 atom in the ring is selected from O or N; heteroaryl, containing 5-6 atoms in a ring, where 1 atom in the ring is selected from O or N; phenyl; each of which can in some cases be substituted with one or several substituents, selected from the group, consisting of a halogen, -S(O)2(C1-C4)alkyl, OH, -C(O)-(C1-C4)alkyl, (C1-C6)alkyl; and R3 is selected in an independent way from the group, consisting of (heteroaryl, containing 6 atoms in a ring, where 1-2 atoms in the ring are selected from N)(C1-C4)alkyl; (bicyclic heteroaryl, containing 9-10 atoms in a ring, where 1-3 atoms in the ring are selected from N)(C1-C4)alkyl; phenyl; phenyl(C1-C4)alkyl; each of which can in some cases be substituted with one substituent, selected from the group, consisting of a halogen, CN, (C1-C4)alkoxy. The invention also relates to a different version of formula (I) compounds, to individual compounds, to a pharmaceutical composition, to the method of treating a PDE9-associated disease or disorder and to the method for PDE inhibition.
EFFECT: improvement of the properties of the compounds.
21 cl, 2 tbl, 58 ex
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