DERIVATIVES OF IMIDAZOPYRIDINES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to the novel derivatives of imidazopyridines of the formula (I) where R means group of the formula (Ia) , R¹ means F; R² is SO₂NHCOR⁵; R³ is A; R⁴ is group of the formula C_nH_2nR⁹; R⁵ is A, C_tH_2t(C₃-C₈)-cycloalkyl), -C_tH_2t-Ar; R⁹ is COOA, Ar-CO-N-R⁶R⁷, -CO-Ar; R⁶ and R⁷ are H, A, Ar-C_nH_2n, respectively, or R⁶ and R⁷ in common mean alkylene chain with C-5; R⁸ means C₁-C₆-alkyl; A is C₁-C₆-alkyl; Ar is unsubstituted phenyl group; t = 0, 1, 2 or 3; n = 1, 2, 3, 4 or 5 or their salts and to method of their synthesis and pharmaceutical composition based on thereof and method of pharmaceutical composition preparing. Indicated compounds and pharmaceutical composition show antagonistic effect with respect to angiotensin-II and can be used for treatment of patients with hypertension, aldosteronism, cardiac insufficiency, central nervous system impairments and other diseases. EFFECT: new compounds indicated above, valuable medicinal properties. 6 cl, 1 tbl, 11 ex