FIELD: biopharmacology, biotechnology, microbiology.
SUBSTANCE: invention relates to methods for industrial preparing the human recombinant granulocyte-colony-stimulating factor (G-CSF) of medicinal designation, and to recombinant Escherichia coli (E. coli) strains and plasmids used for its preparing. Group of inventions involves creature of recombinant plasmid DNA pSX70, constructing recombinant industrial Escherichia coli pSX70 strain-producer deposited in All-Russian collection of Industrial Microorganisms (VKPM), FGUP Gos. NII Genetics at collection number VKPM B-8842. Invention provides preparing G-CSF with the high yield by relatively simple and safety technology that can be used as a base for preparing composition in form of aqueous solution for injection.
EFFECT: improved preparing method, valuable biological properties of strain.
9 cl, 1 dwg, 3 ex
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