FIELD: chemistry.
SUBSTANCE: invention refers to compounds of formula I 
their pharmaceutically acceptable salts and solvate I where X represents O or S; Y and Z mutually independently denote hydrogen or halogen; R1 is hydroxy-C1-C7-alkyl, carboxy, C1-C7-alkyloxycarbonyl, or substitute of formula II 
R2 is hydrogen, carboxy or alkyloxycarbonyl. Compounds can be used as inhibitors of cytokine or inflammation mediator producing. Intermediate compounds of compounds I and application of compounds 1 are also described.
EFFECT: production of compounds used as inhibitors of cytokine or inflammation mediator producing.
12 cl, 1 tbl, 14 ex
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