FIELD: medicine; pharmacology.
SUBSTANCE: pharmaceutical compositions are invented, which decrease the abstinent syndrome manifestations in narcotic opioid drug withdrawal. The compositions contain the optimal proportions of tiapride and clofelin (8000÷1000:1). These compositions, which contain less amount of each drug, demonstrate the potentiation of analgesic activity (which significantly exceeds that in monotherapy with tiapride and clofelin). Also, toxic effect of the compositions is less than that when tiapride and clofelin are administered separately, in mice.
EFFECT: compositions terminate the opiate abstinent syndrome with minimal toxic effect.
3 ex, 4 tbl
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