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2 324 738

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IPC

C12N15/86(2006-01-01)

C12N15/48(2006-01-01)

(21) (22)

Application

2006121114/13, 2006-06-16

(24)

Start date

2006-06-16

(22)

Actual filing date

2006-06-16

(45)

Published

2008-05-20

(72)

Inventor

Churikov Nikolaj AndreevichKretova Ol'Ga Valer'EvnaGashnikova Natal'Ja MatveevnaPokrovskij Andrej Georgievich

(73)

Holder

Federal'Noe Gosudarstvennoe Uchrezhdenie Nauki Nauchnyj Tsentr Virusologii I Biotekhnologii Federal'Noj Sluzhby Po Nadzoru V Sfere Zashchity Prav Potrebitelej I Blagopoluchija Cheloveka Gnts Vb Rospotrebnadzora)Institut Molekuljarnoj Biologii Im. V.A. Ehngel'Gardta Ran

GENETIC CONSTRUCTION ON BASIS OF VECTOR PLASMID pEGFP-N1 PRODUCING siPHK-INHIBITORS OF REPRODUCTION OF THE HUMAN IMMUNE DEFICIENCY VIRUS OF THE 1 TYPE (ITS VARIANTS) Russian patent published in 2008 - IPC C12N15/86 C12N15/48

Abstract RU 2324738 C2

FIELD: chemistry, organic, viruses.

SUBSTANCE: invention relates to medical and molecular genetics. Three geometric constructions are proposed on the basis of vector plasmid pEGFP-N1, the constructions producing siPHK: inhibitors of reproduction of the human immune deficiency virus of the 1 type. The invention may be used in development of more efficient anti-HIV preparations on the basis of interfering RNAs (siPHK) produced in cells with the aid of administered vector expressing constructions.

EFFECT: obtaining of genetic construction for development of anti-HIV preparations.

3 cl, 1 dwg, 5 tbl, 3 ex

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RU 2 324 738 C2

Authors

Churikov Nikolaj Andreevich

Kretova Ol'Ga Valer'Evna

Gashnikova Natal'Ja Matveevna

Pokrovskij Andrej Georgievich

Dates

2008-05-20—Published

2006-06-16—Filed