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2 425 150

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IPC

C12N15/63(2006-01-01)

A61K39/21(2006-01-01)

(21) (22)

Application

2009142859/10, 2009-11-23

(24)

Start date

2009-11-23

(22)

Actual filing date

2009-11-23

(45)

Published

2011-07-27

(72)

Inventor

Churikov Nikolaj AndreevichKretova Ol'Ga Valer'Evna

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Molekuljarnoj Biologii Im. V.A. Ehngel'Gardta RanRossijskaja Federatsija, Ot Imeni Kotoroj Vystupaet Ministerstvo Obrazovanija I Nauki Rossijskoj Federatsii

CARTRIDGE GENETIC MAKER EXPRESSING THREE BIOLOGICALLY ACTIVE siPHK, EFFECTIVELY ATTACKING HUMAN IMMUNODEFICIENCY VIRUS AND CCR5 GENE TRANSCRIPTS BY MEANS OF RNA-INTERFERENCE Russian patent published in 2011 - IPC C12N15/63 A61K39/21

Abstract RU 2425150 C1

FIELD: medicine.

SUBSTANCE: what is described in a cartridge genetic maker based on GeneClip-Ul-neo vector producing three siRNA - reproduction inhibitors of human immunodeficiency virus type 1 and human CCR5 gene. The maker contains a fragment of the length 27 bp related to a conservative region of a HIV-1 genome reverse transcriptase domain, a fragment of the length 27 bp related to the other conservative region of the HIV-1 genome reverse transcriptase domain, as well as a fragment 19 bp related to CCR5 gene mRNA. The invention can be used in medicine and scientific research.

EFFECT: invention allows producing more effective anti-HIV preparations based on interfering RNA produced in cells by means of the introduced cartridge genetic maker containing palindromes for three siRNA production.

3 dwg, 2 tbl, 2 ex

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RU 2 425 150 C1

Authors

Churikov Nikolaj Andreevich

Kretova Ol'Ga Valer'Evna

Dates

2011-07-27—Published

2009-11-23—Filed