INHIBITORS OF TWO SITES OF BINDING ACETYLCHOLINESTERASE FOR TREATMENT OF THE ALZHEIMER'S DISEASE Russian patent published in 2008 - IPC C07D219/12 C07D401/12 A61K31/473 A61P25/28 

Abstract RU 2325379 C2

FIELD: chemistry.

SUBSTANCE: invention relates to new compounds of the formula (I) Formula I , where: X is the following radical: , L is separately selected from -C(R)(R")-, -CO-, NR'-; n equals zero, unity, two, three, four, five, six, seven, eight, nine or ten; R, R' and R" are separately selected from hydrogen, alkyl; D is separately selected from -C(R9)- or -N-; A1 A2, A3, A4, A5, A6, A7, A8, E and G are separately selected from -CO-, -C(R10)(R11)-, =C(R10)-; R1, R2, R3, R9, R10 and R11 are separately selected from hydrogen, alkyl, alkoxyl, hydroxyl, haloge-nalkyl, halogen. The invention relates also to pharmaceutical compositions based on the above substances, to the use of these compounds for production of a pharmaceutical and to the method of treatment of cognitive disturbances. EFFECT: compounds are useful in treatment of cognitive disturbances.

12 cl, 2 tbl, 24 ex.

Similar patents RU2325379C2

Title Year Author Number
TACRINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS 2004
  • Martines Khil' Ana
  • Dorronsoro Dias Isabel'
  • Rubio Arr'Eta Laura
  • Alonso Gordil'O Diana
  • Fuehrtes Uehrta Ana
  • Morales-Alselaj Susana
  • Del' Monte Mil'Jan Marija
  • Garsia Palomero Ehster
  • Usan Ehkhea Paola
  • De Austria Selija
  • Medina Padil'Ja Migel'
  • Mun'Os Ruis Pilar
RU2402545C2
NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE, PHARMACEUTICAL COMPOSITION BASED THEREON, USE THEREOF AND METHOD OF TREATING AND/OR PREVENTING DISEASE 2009
  • Uto Josikazu
  • Karasava Khirosi
  • Takaisi Kijosumi
RU2474575C2
6-(HETEROCYCLYL-SUBSTITUTED BENZYL)-4-OXOQUINOLINE DERIVATIVE AND USE THEREOF AS HIV INTEGRASE INHIBITOR 2007
  • Satokh Motokhide
  • Aramaki Khisateru
  • Jamasita Masaki
  • Inoue Masafumi
  • Kavakami Khirosi
  • Sinkaj Khisasi
  • Nakamura Khirosi
  • Matsuzaki Judzi
  • Vamaki Suiti
RU2399616C1
[1,8]NAPHTHYRIDINE DERIVATIVES, USEFUL AS INHIBITORS OF HCV VIRUS REPLICATION 2006
  • Rokuehj Todd V.
  • Betebenner Dehvid A.
  • Krjuger Allan K.
  • Ivasaki Nobukhiko
  • Kuper Kert S.
  • Anderson Dehvid D.
  • Kempf Dejl Dzh.
  • Mejdigan Dehrold L.
  • Motter Kristofer E.
  • Shehnli Dzhejson P.
  • T'Jufano Majkl D.
  • Vagner Rol'F
  • Chzhan Zhun
  • Molla Akkhteruzzaman
  • Mo Khunmehj
  • Pajlot-Matias Tami
  • Masse Sheri Vl.
  • Kehrrik Robert Dzh.
  • Kheh Vepin
  • Lu Ljantszjun'
RU2467007C2
NOVEL COUMARIN DERIVATIVES WITH ANTI-TUMOUR ACTIVITY 2007
  • Iikura Khitosi
  • Kheudokh Ikumi
  • Aoki Tosikhiro
  • Furuiti Norijuki
  • Matsusita Masajuki
  • Vatanabe Fumio
  • Ozava Savako
  • Sakajtani Masakhiro
  • Kho Pil-Su
  • Tomii Jasusi
  • Takanasi Kendzi
  • Kharada Naoki
RU2428420C2
INDOLE AND INDAZOLE DERIVATIVES SHOWING PRESERVING ACTION ON CELLS, TISSUES AND ORGANS 2009
  • Kim Soon Kha
  • Kim Khioung Dzin
  • Chung Chul Voong
  • Park Kheui Sul
  • Kvak Khio Shin
  • Kim Sung Kho
  • Park Dzin Gu
RU2460525C2
MODULATORS OF ATP-BINDING CARTRIDGE TRANSPORTERS 2005
  • Adida Rua Sara S.
  • Khejzlvud Anna R.
  • Grotenkhejs Peter D.,J.
  • Van Gur Frederik F.
  • Singkh Ashvani K.
  • Chzhou Tszinlan'
  • Makkartni Dzhejson
RU2528046C2
ATP-BINDING CASETTE TRANSPORTER MODULATORS 2005
  • Adida Rua Sara S.
  • Khejzlvud Anna R.
  • Grotenkhejs Peter D. J.
  • Van Gur Frederik F.
  • Singkh Ashvani K.
  • Chzhou Tszinlan'
  • Makkartni Dzhejson
RU2382779C2
METHOD OF MODULATING TRANSPORTERS OF ATP-BINDING CASSETTE 2005
  • Adida Rua Sara S
  • Khejzlvud Anna R
  • Grotenkhejs Peter D J
  • Van Gur Frederik F
  • Singkh Ashvani K
  • Chzhou Tszinlan'
  • Makkartni Dzhejson
RU2525115C2
ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF FOR INHIBITING NOREPINEPHRINE, DOPAMINE AND SEROTONIN REUPTAKE 2005
  • Molino Brjus F.
  • Lju Shuan
  • Berkovits Behrri A.
  • Gazzo Piter R.
  • Bek Dzhejms P.
  • Kokhen Marlin
RU2388751C2

RU 2 325 379 C2

Authors

Martines Khil Ana

Dorronsoro Dias Isabel'

Rubio Arr'Eta Laura

Alonso Gordil'O Diana

Fuehrtes Uehrta Ana

Morales-Alselaj Susana

Del' Monte Mil'Jan Marija

Garsia Palomero Ehster

Usan Ehkhea Paola

De Austria Selija

Medina Padil'Ja Migel'

Dates

2008-05-27Published

2003-10-07Filed