FIELD: chemistry.
SUBSTANCE: invention relates to new compounds of the formula (I) Formula I , where: X is the following radical: , L is separately selected from -C(R)(R")-, -CO-, NR'-; n equals zero, unity, two, three, four, five, six, seven, eight, nine or ten; R, R' and R" are separately selected from hydrogen, alkyl; D is separately selected from -C(R9)- or -N-; A1 A2, A3, A4, A5, A6, A7, A8, E and G are separately selected from -CO-, -C(R10)(R11)-, =C(R10)-; R1, R2, R3, R9, R10 and R11 are separately selected from hydrogen, alkyl, alkoxyl, hydroxyl, haloge-nalkyl, halogen. The invention relates also to pharmaceutical compositions based on the above substances, to the use of these compounds for production of a pharmaceutical and to the method of treatment of cognitive disturbances. EFFECT: compounds are useful in treatment of cognitive disturbances.
12 cl, 2 tbl, 24 ex.
Title | Year | Author | Number |
---|---|---|---|
TACRINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS | 2004 |
|
RU2402545C2 |
NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE, PHARMACEUTICAL COMPOSITION BASED THEREON, USE THEREOF AND METHOD OF TREATING AND/OR PREVENTING DISEASE | 2009 |
|
RU2474575C2 |
6-(HETEROCYCLYL-SUBSTITUTED BENZYL)-4-OXOQUINOLINE DERIVATIVE AND USE THEREOF AS HIV INTEGRASE INHIBITOR | 2007 |
|
RU2399616C1 |
[1,8]NAPHTHYRIDINE DERIVATIVES, USEFUL AS INHIBITORS OF HCV VIRUS REPLICATION | 2006 |
|
RU2467007C2 |
NOVEL COUMARIN DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | 2007 |
|
RU2428420C2 |
INDOLE AND INDAZOLE DERIVATIVES SHOWING PRESERVING ACTION ON CELLS, TISSUES AND ORGANS | 2009 |
|
RU2460525C2 |
MODULATORS OF ATP-BINDING CARTRIDGE TRANSPORTERS | 2005 |
|
RU2528046C2 |
ATP-BINDING CASETTE TRANSPORTER MODULATORS | 2005 |
|
RU2382779C2 |
METHOD OF MODULATING TRANSPORTERS OF ATP-BINDING CASSETTE | 2005 |
|
RU2525115C2 |
ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF FOR INHIBITING NOREPINEPHRINE, DOPAMINE AND SEROTONIN REUPTAKE | 2005 |
|
RU2388751C2 |
Authors
Dates
2008-05-27—Published
2003-10-07—Filed