MODULATORS OF ATP-BINDING CARTRIDGE TRANSPORTERS Russian patent published in 2014 - IPC C07D215/48 A61K31/47 A61P25/00 A61P31/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a compound of formula (VA-1), wherein WR^W2 and WR^W4 are independently specified in a hydrogen atom, -CN, -CF₃, halogen, linear or branched (C₁-C₆)alkyl, a 3-12-merous cycloaliphatic group or phenyl, wherein WR^W2 and WR^W4 are independently and optionally substituted by up to three substitutes specified in -OR′, -CF₃, -OCF₃, -SR′, -S(O)R′, -SO₂R′, halogen, -CN, -COOR′, -(CH₂)OR′, -CH₂CN, phenyl, phenoxy group, -N(R′)(R′), -NR′C(O)OR′, -NR′C(O)R′, -(CH₂)N(R′)(R′); WR^W5 is specified in a group consisting of a hydrogen atom, -CN, -CHF₂, -N(R′)₂, -NHC(O)R′, -NHC(O)OR′, -NHSO₂R′, -OR′, -CH₂OH, -CH₂N(R′)₂, -C(O)OR′, -SO₂NHR′, -SO₂N(R′)₂ or -CH₂NHC(O)OR′; X means a bond; R^x means the hydrogen atom; R′ is independently specified in the hydrogen atom, (C₁-C₈)aliphatic group, (C₃-C₈)cycloalkyl or phenyl. Also, the invention refers to a pharmaceutical composition possessing the properties of modulators of ATP-binding cartridge (ABC) transporters and containing the compound of formula , and to a method of treating or relieving a severity in a patient, wherein the above disease is specified in mucoviscidosis, hereditary emphysema, chronic obstructive pulmonary disease (COPD) or dry eye disease.

EFFECT: compound of formula (VA-1) as the modulators of the ATP-binding cartridge (ABC) transporters.

24 cl, 14 tbl, 83 ex