6-(HETEROCYCLYL-SUBSTITUTED BENZYL)-4-OXOQUINOLINE DERIVATIVE AND USE THEREOF AS HIV INTEGRASE INHIBITOR Russian patent published in 2010 - IPC C07D215/56 C07D401/10 C07D413/10 C07D417/10 A61K31/4709 A61K31/496 A61K31/5377 A61K31/541 A61P31/18 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula

or its pharmaceutically acceptable salt or its solvate, where ring A is a monocyclic heterocyclic group optionally substituted with 1-2 substitutes selected from the following group A, where the monocyclic heterocyclic group is selected from 1-pyrrolidinyl group, 2-oxopyrrolidin-1-yl group, piperidine group, 2-oxopiperidin-1-yl group, 1-piperazinyl group, morpholine group, 3-oxomorpholin-4-yl group, thiomorpholine group, 1,1-dioxoisothiazolin-2-yl group, 2-pyridyl group, 2-thiazolyl group and 1,2,4-oxadiazol-3-yl group; group A consists of a halogen atom, C_1-4alkyl group, -(CH₂)n-OR^a1 and -COR^a2, where R^a1 and R^a2 are identical or different and each of them is a hydrogen atom or a C_1-4alkyl group and n equals 0; R¹ is a C_1-6alkyl group optionally substituted with 1 substitute selected from the following group B; group B consists of -OR^b1, where R^b1 is a C_1-4alkyl group; R² is a hydrogen atom, C_1-4alkyl group or -OR¹¹, where R¹¹ is an atom, C_1-4alkyl group; R³ and R⁴ are identical or different and each is a halogen atom; R⁵ is a halogen atom; m equals 0 or 1; and R⁶ is a hydrogen atom. The invention also relates to a pharmaceutical composition, anti-HIV agent, HIV integrase inhibitor, anti-HIV compositions which contain an active ingredient in form of a formula I compound; to use of formula I compounds to prepare an anti-HIV agent and HIV integrase inhibitor; to a method of preventing or treating infectious diseases caused by HIV and to a method of inhibiting HIV integrase in mammals, involving administration of formula I compounds.

EFFECT: useful biological properties.

27 cl, 9 tbl, 67 ex