NEW BICYCLIC LIPASE HORMONES INHIBITORS Russian patent published in 2008 - IPC C07D401/06 C07D403/06 A61K31/4196 A61P3/10 

FIELD: chemistry.

SUBSTANCE: new derivatives of benzotriazol of folrmula I are described where Rl-R8-H, and one of residues R2 or R3 (IT) can designate Br, CI,_{CH3, CN,NH2, NO2,CF3, OCH3, phenoxy, benzoil, CH(OH)-phenyl, S-cyclohexyl,CO-OCH3; or two substitutors from this series designate Rl=Cl andR3=CF3 or R2=F and R3=Cl; n - an integer 0, 1 or 2; and one of substitutors R6 or R7 can designate R6 - CH3; R7 - CH3, C2H5; CH (CH3)2, C(CH3)3, CF3, Br, Cl, benzil or CO-OC2H5; or R6 and R7 both designate CH3; or the ring instead of R6 and R7 can contain double bond, or R5 and R6, or R6 and R7 can designate together with atoms C to which they are bonded, benzanilated ring, or in case of n=0 also cyclohexandiil, here, in case of ring formation of R6/R7, this substitutor can be unitary replaced by ofNH2 orNO2,if required, or one-twiceOCH3 and R7 and R8 together designate cyclopenthyl, diazepin or CH2; except for compounds, where R1-R5 and R8=H, n=l and R6/R7=benzanilated ring, and Rl, R3-R8=H,R2=CH3 and n=1, the method of their production and a pharmaceutical for treatment of not achrestic diabetes or a diabetic syndrome.}

EFFECT: new compounds possess useful biological properties.

12 cl, 55 ex