PHENYLAMINOBENZOXAZOLE-SUBSTITUTED CARBOXYLIC ACIDS, SYNTHESIS METHOD THEREOF AND USE THEREOF AS MEDICINAL AGENTS Russian patent published in 2011 - IPC C07D263/58 C07D413/12 A61K31/423 A61P3/06 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula I, where R¹ denotes H; R⁶, R⁷, R⁸, R⁹, R¹⁰ independently denote H, F, Cl, Br, CF₃, OCH₃, OCF₃, OCHF₂, SCH₃, SCF₃, phenyl, (C₁-C₆)-alkyl, O-(C₁-C₆)-alkyl or NR³R⁴, where the alkyl and phenyl can be substituted with R² once or many times, and where any two residues from R⁶, R⁷, R⁸, R⁹, R¹⁰ in neighbouring positions of the phenyl ring can form a -CH=CH-CH-CH- residue together; m equal 0, 1, 2 or 3; X denotes -(CH₂)₂-; R² denotes F, Cl, Br, CN, OCH₃, OCF₃, CH₃, CF₃, (C₁-C₆)-alkyl or O-(C₁-C₆)-alkyl, where the alkyl can be substituted once or many times with OH, F, Cl, Br or CN; R³, R⁴ independently denote H or (C₁-C₆)-alkyl; or physiologically acceptable salts thereof, provided that the compound 3-(2-o- tolylamino-benzoxazol-6-yl)-propionic acid is excluded. The invention also relates to use of compounds of formula (I) to prepare a medicinal agent which activates GPR40 receptors and use of said compounds to prepare a medicinal agent for lowering blood sugar level, for treating diabetes and for increasing insulin secretion.

EFFECT: compounds of formula I which activate GPR40 receptors are obtained.

6 cl, 2 tbl, 146 ex