DERIVATIVES OF 5B-SAPOGENIN AND PSEUDO SAPOGENIN AND APPLICATION FOR DEMENTIA MEDICAL TREATMENT Russian patent published in 2008 - IPC C07J71/00 A61K31/58 A61P25/28 A61P25/14 A61P25/16 

FIELD: chemistry.

SUBSTANCE: invention discovers derivatives of 5β-sapogenin and pseudo sapogenin of general formula or , where in general formula I or II: R₁ R₂, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃ and R₁₅ if available-H, independently R₁ and R₁₃-OH or R₃-OH, =O or OR, where R - optionally substituted alkyl; lower acyl optinally substituted with carbamonyl or amino or lower alkoxycarbamonyl; lower alkoxycarbamonyl; R₁₄ lower alkyl, optionally double bond with the exception of smylagenin and those compounds of formula I where simultaneously R₁= R₂= R₄= R₅= R₆= R₇= R₈=^{R₉= R₁₀= R₁₁= R₁₂= R₁₃=H, R₃=β OH, R₁₄=CH₃, and methyl in C20 condition has α-orientation and C25 has S-configuration.}

EFFECT: compounds increases muscarine receptor number and are useful for enhancement of human or animal cognitive function.

12 cl, 17 ex, 5 dwg, 21 tbl