FIELD: chemistry.
SUBSTANCE: invention relates to a compound of formula IV, wherein R6 and R7 are independently halogen, -SO2NH2, -COOH or H; R2 and R5 represent H; in free form or in form of a pharmaceutically acceptable salt. Compound of formula IV binds to nicotinic acetylcholine receptor with high affinity. Invention also relates to a pharmaceutical composition and method of treating, or preventing a disease or disorder, characterised by activation of acetylcholine receptor pathway.
EFFECT: for example, compounds and methods of treating function as blocking activity of certain acetylcholine receptors and their subtypes and are used to treat diseases and conditions mediated by irritation of nicotinic receptors, for example small cell lung cancer, symptoms of cognitive impairment, such as Alzheimer's disease.
26 cl, 2 tbl, 13 ex
| Title | Year | Author | Number |
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| ORGANIC COMPOUNDS | 2014 |
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RU2679142C2 |
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RU2756604C2 |
| NICOTINIC RECEPTOR LIGANDS | 2007 |
|
RU2441007C2 |
| DIAZABICYCLIC ARYL DERIVATIVES AS LIGANDS OF NICOTINIC ACETYLCHOLINE RECEPTORS | 2005 |
|
RU2367665C2 |
| 1-AZABICYCLO[3,3,1]NONANES DERIVATIVES | 2005 |
|
RU2445313C2 |
| POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR | 2012 |
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RU2604737C2 |
| AZA-ADAMANTANE DERIVATIVE MONOHYDRATE | 2011 |
|
RU2579121C2 |
| SPIRO-AZABICYCLIC COMPOUNDS, METHODS OF THEIR SYNTHESIS AND INTERMEDIATE COMPOUNDS | 1995 |
|
RU2148058C1 |
| RECEPTOR SUBTYPE-SELECTIVE AZABICYCLOALKANE DERIVATIVES | 2008 |
|
RU2417984C1 |
| NEW DIAZABICYCLIC ARYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE | 2004 |
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