FIELD: medicine; pharmacology.
SUBSTANCE: described method of stereo-specific production of 3(3-hydroxy-5β-H steroid sapogen or its derivatives by reduction of 3-keto,5β-H-steroid sapogenine with steric unfavoured organ-borane. 3β-Hydroxy,5β-H- steroid sapogenine or its derivative can be produced by reduction of 3-keto,5β-H- steroid sapogenine with relatively high steric unfavoured organ-borane reagent used as reducing agent, or by SN2 transformation of 3α-hydroxy,5β-H- steroid sapogenine or its derivative. Method represents easy way of steroid sapogenine production, such as sarsasapogenine, epysarsasapogenine, smylagenine, epysmylagenine andtheir esters using available or easy-made original substances (e.g., diosgenone, preferably of diosgenine).
EFFECT: improved method of composition production.
43 cl, 11 ex, 3 tbl, 1 dwg
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