TRICYCLIC DERIVATIVES OR THEIR PHARMACEUTICAL SALTS, METHOD OF OBTAINING THEM AND THEIR PHARMACEUTICAL COMPOUNDS Russian patent published in 2008 - IPC C07C323/30 C07D213/81 C07D333/38 A61K31/165 A61K31/381 A61K31/44 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention pertains to tricyclic derivatives, represented by formula (I) or to their pharmaceutical salts, which have proliferative activity and ability to inhibit angiogenesis, to the method of obtaining them (alternatives), the proliferative agent and an angiogenesis inhibitor on their base. , where R₁ represents T₁B₁; Ti represents -N(R₅)C(O)-, where R₅ represents H or C₁-C₅ alkyl group; and B₁ is chosen from a group, consisting of the following values (a),(b),(f),(g): , where represents , or ; R₆ represents H, halogen or hydroxy group; R₇ represents a hydroxy or -ONO₂ group, under the condition that R₆ represents H, R₇ is different from hydroxyl; T₂ represents -O-C(O)-; B₂ the stated (a) group or -Z₁-R₇, where Z₁ represents a linear C₂-C₅alkyl group, n₂ represents an integer 0-3; and n₃ represents an integer 0-5; R₂ represents CH₃; R₃ represents C_1-C₄ unbranched or branched alkyl, or C₃-C₇ cycloalkyl, under the condition that, if B₁ represents (a), R₆ represents H, R₇ represents an -ONO₂ group and R₃ is not CH₃; R₄ represents SCH₃ or OCH₃; X represents O.

EFFECT: perfection of the method of obtaining compounds.

7 cl, 6 tbl, 14 dwg, 48 ex