TRICYCLIC DERIVATIVES OR THEIR PHARMACEUTICAL SALTS, METHOD OF OBTAINING THEM AND THEIR PHARMACEUTICAL COMPOUNDS Russian patent published in 2008 - IPC C07C323/30 C07D213/81 C07D333/38 A61K31/165 A61K31/381 A61K31/44 A61P35/00 

Abstract RU 2326864 C2

FIELD: chemistry.

SUBSTANCE: invention pertains to tricyclic derivatives, represented by formula (I) or to their pharmaceutical salts, which have proliferative activity and ability to inhibit angiogenesis, to the method of obtaining them (alternatives), the proliferative agent and an angiogenesis inhibitor on their base. , where R1 represents T1B1; Ti represents -N(R5)C(O)-, where R5 represents H or C1-C5 alkyl group; and B1 is chosen from a group, consisting of the following values (a),(b),(f),(g): , where represents , or ; R6 represents H, halogen or hydroxy group; R7 represents a hydroxy or -ONO2 group, under the condition that R6 represents H, R7 is different from hydroxyl; T2 represents -O-C(O)-; B2 the stated (a) group or -Z1-R7, where Z1 represents a linear C2-C5alkyl group, n2 represents an integer 0-3; and n3 represents an integer 0-5; R2 represents CH3; R3 represents C1-C4 unbranched or branched alkyl, or C3-C7 cycloalkyl, under the condition that, if B1 represents (a), R6 represents H, R7 represents an -ONO2 group and R3 is not CH3; R4 represents SCH3 or OCH3; X represents O.

EFFECT: perfection of the method of obtaining compounds.

7 cl, 6 tbl, 14 dwg, 48 ex

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RU 2 326 864 C2

Authors

Kim Miung-Khva

Chung Kvangvoo

Choj Dzae-Von

Dzoe Bo-Jang

Park Sang-Voo

Kim Kvang-Khee

Okh Biung-Kiu

Choj Dzong-Khee

Dates

2008-06-20Published

2004-06-23Filed