PYRIMIDINE COMPOUNDS OF ANTIPROLIFERATIVE ACTION (II) Russian patent published in 2008 - IPC C07D487/04 A61K31/519 A61P35/04 

Abstract RU 2326882 C2

FIELD: medicine; pharmacology.

SUBSTANCE: new discovered pyrimidine compounds of formula where R1-R9 are those as specified are selective inhibitors of group Src of nonreceptor tyrosine kinases. These compounds and their pharmaceutically acceptable salts are antiproliferative agents applied for treatment and fight against solid tumours, specifically breast tumours, rectum tumours, liver and pancreatic tumours.

EFFECT: applicable for cancer treatment.

17 cl, 5 dwg, 16 ex, 1 tbl

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RU 2 326 882 C2

Authors

Luk Kin'Chun'

Rossman Pamela Lorin

Shajblikh Shtefan

So Sunsau

Dates

2008-06-20Published

2003-10-27Filed