FIELD: medicine; pharmacology.
SUBSTANCE: new discovered pyrimidine compounds of formula where R1-R9 are those as specified are selective inhibitors of group Src of nonreceptor tyrosine kinases. These compounds and their pharmaceutically acceptable salts are antiproliferative agents applied for treatment and fight against solid tumours, specifically breast tumours, rectum tumours, liver and pancreatic tumours.
EFFECT: applicable for cancer treatment.
17 cl, 5 dwg, 16 ex, 1 tbl
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Authors
Dates
2008-06-20—Published
2003-10-27—Filed