FIELD: chemistry, pharmaceuticals.
SUBSTANCE: derivatives of pyrimido {4,5-D}pyrimidine, with anticancer activity 
, in which R1 and R9 are defined in the description and are selective inhibitors of kinase RCK (receptor, containing a kinase insertion domain) and RFGF (receptor, fibroblast growth factor) and selective to LCK (T-cell tyrosine kinase p56lck). These compounds and their pharmaceutical salts have antiproliferative activity and are used treating and fighting solid tumours, particularly mammary tumours, straight intestine, and lung and prostate gland tumours. Pharmaceutical compositions containing these compounds are also invented, as well as their use in treating cancer.
EFFECT: obtaining derivatives, which have anticancer activity.
12 cl, 27 ex, 2 tbl
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