FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention concerns to 3,4-disubstituted tsiklobuten-1,2-diones of the formula I or their pharmaceutically to comprehensible salts or solvates, 
. A is chosen from the group including 
X=-O-, -NH-, -S-,
.
n=1-5
B is chosen from the group including 
. The bonds can be used at treatment of mediated chemokine diseases, such as acute both chronic inflammatory diseases and a cancer. The pharmaceutical composition and application of bonds I are also described.
EFFECT: obtaining of bonds which can be used at treatment of mediated chemokine diseases, such as acute both chronic inflammatory diseases and cancer.
50 cl, 31 ex
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