PYRIMIDINE COMPOUNDS WITH SELECTIVE INHIBITION OF "¦-¦" AND "L¦L¦" ACTIVITY Russian patent published in 2009 - IPC C07D487/04 C07D239/46 C07D239/42 A61K35/00 C07F7/10 

FIELD: chemistry; pharmacology.

SUBSTANCE: invention refers to new pyrimidine compounds of formula (I) with selective inhibition of "КДР" and "ФРФР" kinase. These compounds and their pharmaceutically acceptable salts are antiproliferative agents. In formula (I) , where R¹ is chosen from series including -H, -(CH₂)_n -5-6-merous heterocycle containing 1-2 heteroatoms chosen from nitrogen, sulphur oxygen or dioxide, (C₁-C₆)alkyl, (C₃-C₆)cycloalkyl where n stands for 0, and each groups including heterocycle, alkyl, cycloalkyl is independently optionally substituted to three groups chosen from: -OR⁹, -COR¹⁰, -CO₂R¹⁰, -CONR¹⁰R¹¹ and -CN; R² stands for -H or -OCH₃; R³ stands for -H, -F or -OCH₃; R⁴, R⁵ and R⁷ stand for -H, R⁶ means (C₁-C₆)alkyl or OR¹²; R⁸ stands for -H or -F; R⁹ stands for -H and (C₁-C₆)alkyl, (C₁-C₆)alkoxide R¹⁰ and R¹¹ independently are chosen from -H and (C₁-C₆)alkyl, (C₁-C₆)alkoxy, and R¹² stands for -H and (C₁-C₆)alkyl.

EFFECT: can be used for treating and preventing solid cancers, specifically breast, rectum, lung and prostate cancer.