FIELD: technological processes; veterinary medicine.
SUBSTANCE: method consists in the following: in cells LMH homologous recombination is performed between genomic DNA of birds adenovirus CELO with deleted right end fragment and plasmid structure, which contains the right end fragment of CELO genome with deletion in 3620 bps, in the area of which the expressing cassette with gene of birds flu virus H5N1 hemagglutinin is cloned, or with gene of birds flu virus H5N1 neuraminidase, or with both above mentioned genes.
EFFECT: creation of genetically engineered recombinant vaccines of new generation.
4 cl, 5 dwg, 7 ex
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