FIELD: biotechnologies.
SUBSTANCE: invention relates to the biotechnology. Described is the MDCK, the influenza virus protein producing cell, containing a lentiviral plasmid vector pLenti6.3/TO/HA(H1N1)-M1-NA, containing influenza virus (H1N1) protein the hemagglutinin, neuraminidase and M1 genes, shown in fig. 3. Described is the MDCK, the influenza virus protein producing cell, containing a lentiviral plasmid vector pLenti6.3/TO/HA(H3N2)-M1-NA, containing the cloned hemagglutinin gene from the H3N2 subtype strain, as well as the neuraminidase and the M1 protein genes of the (H1N1) subtype strain shown in fig. 2. Described is the MDCK, the influenza virus protein producing cell, containing a lentiviral plasmid vector pLenti6.3/TO/HA(B-)-M1-NA, containing the influenza B virus hemagglutinin gene, as well as the neuraminidase and the M1 protein genes of the (H1N1) influenza virus, shown in fig. 1.
EFFECT: influenza virus MDCK producing cell is used for the influenza virus the virus-like particles (HPV) development.
11 cl, 23 dwg, 6 ex, 10 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING A POLYVALENT INFLUENZA VACCINE | 2018 |
|
RU2701953C1 |
| MULTIVALENT INFLUENZA VACCINE | 2018 |
|
RU2706191C1 |
| CONCENTRATE OF INFLUENZA VACCINE AND METHOD FOR ITS PREPARATION | 2018 |
|
RU2706544C1 |
| LENTIVIRUS PLASMIDA (OPTIONS), METHOD FOR ITS OBTAINING (OPTIONS), SET OF PRIMERS FOR OBTAINING LENTIVIRUS PLASMID VECTOR (OPTIONS) | 2018 |
|
RU2680537C1 |
| METHOD OF CONTROLLING PRODUCTION OF A VACCINE AGAINST INFLUENZA | 2018 |
|
RU2701959C1 |
| INFLUENZA VIRUS THE VIRUS-LIKE PARTICLE AND ITS OBTAINING METHOD | 2018 |
|
RU2681439C1 |
| CASSETTE INTENDED FOR OBTAINING PLASMID VECTORS USED TO CREATE CELL PRODUCERS OF VIRUS-LIKE PARTICLES (VLP) OF INFLUENZA VIRUS | 2018 |
|
RU2680703C1 |
| STRAIN OF BACTERIA ESCHERICHIA COLI - PRODUCER OF RECOMBINANT PROTEIN NS1 | 2021 |
|
RU2789735C1 |
| EFFECTIVE INFLUENZA VLPS | 2004 |
|
RU2369405C2 |
| RECOMBINANT STRAIN OF A/PR8-NS124-Luc INFLUENZA VIRUS AND METHOD FOR EVALUATING POST-VACCINAL NEUTRALIZING ANTIBODIES USING BIOLUMINESCENT DETECTION | 2019 |
|
RU2759054C2 |
