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2 321 631

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IPC

C12N7/01(2006-01-01)

A61K39/00(2006-01-01)

A61P9/10(2006-01-01)

(21) (22)

Application

2005119667/13, 2005-06-24

(24)

Start date

2005-06-24

(22)

Actual filing date

2005-06-24

(45)

Published

2008-04-10

(72)

Inventor

Konstantinov Boris AlekseevichGavrilenko Aleksandr Vasil'EvichBochkov Nikolaj PavlovichNaroditskij Boris Savel'EvichTarantul Vjacheslav ZalmanovichVoronov Dmitrij AleksandrovichKhajdarova Nehlla Vasil'EvnaGintsburg Aleksandr LeonidovichSverdlov Evgenij DavidovichAvdeeva Svetlana Vladimirovna

(73)

Holder

Gosudarstvennoe Uchrezhdenie Rossijskij Nauchnyj Tsentr Khirurgii RamnInstitut Molekuljarnoj Genetiki RanGosudarstvennoe Uchrezhdenie Nauchno-Issledovatel'Skij Institut Ehpidemiologii I Mikrobiologii Im.Pochetnogo Akademika N.F.Gamalei Ramn

NON-INFECTIOUS FOR HUMAN ADENOVIRUS AS VECTOR FOR SUBSTITUTION GENETIC THERAPY OF ANGIOGENESIS DISORDER PROVIDING EFFECTIVE SYNTHESIS OF HUMAN ANGIOGENIN IN MAMMALIAN TRANSFECTED CELLS, METHOD FOR ANGIOGENESIS INDUCTION, METHOD FOR TREATMENT OF ISCHEMIC DISEASE, COMPOSITION FOR INDUCTION OF ANGIOGENESIS AND TREATMENT OF ISCHEMIC DISEASE Russian patent published in 2008 - IPC C12N7/01 A61K39/00 A61P9/10

Abstract RU 2321631 C2

FIELD: medicine, biotechnology, genetic engineering.

SUBSTANCE: invention proposes non-infectious for human adenovirus as a vector for substitution genetic therapy of angiogenesis disorders. This adenovirus is replicative-defect in mammalian cells (including humans) in region that is not essential for replication in avian cells and carries expression cassette consisting of cytomegalovirus promoter, human angiogenin gene cDNA and polyadenylation signal of bovine hormone growth, and provides induction of angiogenesis. Invention proposes a method for induction of angiogenesis and method for treatment of ischemic disease by using a composition comprising the proposed recombinant adenovirus. Invention can be used in medicine in treatment of cardiovascular diseases.

EFFECT: valuable medicinal properties of adenovirus and composition.

5 cl, 1 dwg, 4 ex

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RU 2 321 631 C2

Authors

Konstantinov Boris Alekseevich

Gavrilenko Aleksandr Vasil'Evich

Bochkov Nikolaj Pavlovich

Naroditskij Boris Savel'Evich

Tarantul Vjacheslav Zalmanovich

Voronov Dmitrij Aleksandrovich

Khajdarova Nehlla Vasil'Evna

Gintsburg Aleksandr Leonidovich

Sverdlov Evgenij Davidovich

Avdeeva Svetlana Vladimirovna

Dates

2008-04-10—Published

2005-06-24—Filed