FIELD: medicine; pharmacology.
SUBSTANCE: invention refers to solid dosed composition for pain treatment, containing: nucleus including active pharmaceutical ingredient and matrix, an coating including physical compound of polyvinyl acetate, polyvinyl pyrrolidone and active pharmaceutical ingredient, where active pharmaceutical ingredient and matrix are interconnected in such a way that release of pharmaceutical ingredient placed within nucleus from matrix is controlled, and release of composed active ingredient placed within nucleus occurs more slowly than release of active pharmaceutical ingredient placed in coating matrix. Yet nucleus and coating active pharmaceutical ingredient is the same and considered to tramadole or its stereoisomer or pharmaceutically acceptable salt. Invention also refers to tablet containing specified composition. Composition under invention provides pain relief not later than 2 hour after primary introduction in one dosage; pain relief lasts within at least 24 hours after introduction.
EFFECT: agent is characterised by high efficiency.
14 cl, 7 dwg, 9 tbl, 6 ex
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Authors
Dates
2008-07-10—Published
2003-10-27—Filed