FIELD: medicine.
SUBSTANCE: invention is related to a two-layer composition for acetaminophen and tramadol delivery for at least twelve-month period after the initial introduction. A first layer determines fast release of a part of the composition and contains acetaminophen. A second layer determines continuous release of a part of the composition and contains acetaminophen, tramadol and cross-linked high-amylose starch. The single introduction of the two-layer composition may provide an anaesthising effect for a period of time within the range of a half an hour to approximately one hour after the introduction making at least twelve hours after the initial introduction.
EFFECT: two-layer compositions under the invention may be used for providing both fast, and continuous anaesthising effect in a patient in need thereof.
24 cl, 10 dwg, 5 tbl, 5 ex
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