COMPOSITION COMPRISING HYDROCORTISONE Russian patent published in 2018 - IPC A61K9/50 A61K31/573 A61K47/00 A61P5/38 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions refers to the chemical-pharmaceutical industry and is a pharmaceutical composition for oral administration for the treatment of adrenal insufficiency, comprising a carrier in the form of microparticles; drug layer comprising an effective amount of hydrocortisone and a binding agent; insulating polymer layer containing at least 14% w/w. hydroxypropylmethylcellulose and 1-2% w/w. magnesium stearate, contacting said layer of the drug, wherein said insulating polymer layer separates the drug layer and the taste-masking polymer layer containing at least 0.14% w/w. hydroxypropylmethylcellulose and at least 0.58% w/w. ethylcellulose contacting said insulating layer. Invention also provides a method of treatment for monitoring adrenal insufficiency in children, including administering an effective amount of the composition.

EFFECT: hydrocortisone in the proposed composition is released immediately, after a small delay phase.

18 cl, 3 dwg, 6 tbl, 3 ex