CRYSTAL FORM OF 4-(3-CHLORINE-4-(CYCLOPROPYLAMINOCARBONYL)AMINOPHENOXY)-7-METHOXY-6-QUINOLINECARBOXAMIDE SALT OR ITS SOLVATE AND METHODS FOR ITS PRODUCING Russian patent published in 2008 - IPC C07D215/48 A61K31/47 A61P9/10 A61P17/06 A61P27/02 A61P29/00 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to the crystal forms of methanesulfonate (A, B and C forms), methanesulfonate hydrate (F form), solvate with the acetic acid of methanesulfonate (I form), ethanesulfonate (α and β forms), hydrochloride, hydrobromide, n-toluenesulfonate or sulfate 4-(3-chlorine-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide, to the methods of their production, to the pharmaceutical compositions based on them and showing the angiogenesis related activity, to the method of prevention or treatment of the disease where inhibiting angiogenesis is effective and to the application of the crystal forms in producing the pharmaceutical agent for prevention or treatment of the disease where inhibiting angiogenesis is effective.

EFFECT: producing the pharmaceutical agent for prevention or treatment of the disease where inhibiting angiogenesis is effective.

45 cl, 21 dwg, 27 tbl, 13 ex