CRYSTALLINE CLOPIDOGREL NAPHTALENE SULFONATE OR ITS HYDRATE, METHODS FOR ITS PRODUCING AND PHARMACEUTICAL COMPOSITION Russian patent published in 2008 - IPC C07D495/04 A61K31/4365 A61P9/00 

FIELD: chemistry.

SUBSTANCE: invention relates to the novel form of the crystalline clopidogrel naphthalenesulfonate with formula Ia: for which the powder X-ray diffraction scanning reveals the principal peaks with the I/I₀ values more than 10% at 2θ=6.7, 8.2, 8.5, 12.4, 13.0, 13.5, 16.8, 17.2, 18.9, 19.6, 20.2, 21.2, 22.3, 22.9, 23.2, 23.6, 24.7, 25.0, 25.3, 25.8, 27.0, 27.5, 28.0, 28.6, 32.1, 32.5, 34.7. and monohydrate crystalline clopidogrel 1,5-naphthalenesulfonate with formula (Ib) for which the powder X-ray diffraction scanning reveals the principal peaks with the I/I₀ values more than 10% at 2θ=7.6, 9.7, 10.7, 11.0, 12.1, 13.6, 14.2, 15.3, 16.6, 17.0, 18.1, 18.5, 19.8, 21.5, 22.2, 23.0, 23.5, 24.3, 24.8, 25.7, 26.4, 26.9, 27.3, 28.4, 29.0, as well as to the method of their production and to their pharmaceutical composition.

EFFECT: increased stability of compounds.

10 cl, 8 dwg, 9 tbl, 4 ex