COMPOSITION OF CLOPIDOGREL AND SULPHOALKYLESTER CYCLODEXTRIN (VERSIONS) AND METHODS OF TREATING DISEASES BY SAID COMPOSITION (VERSIONS) Russian patent published in 2012 - IPC A61K31/4365 A61K47/40 A61P7/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention provides compositions containing clopidogrel and sulphoalkylester cyclodextrin (SAE-CD), preferentially, sulphobutylester cyclodextrin. The compositions may be liquid, suspension and solid. The compositions are prepared for ingestion, oral or enteral introduction. SAE-CD is used as an agent promoting clopidogrel dissolution and stabilisation in an aqueous media. Higher stability of clopidogrel to hydrolytic, thermal and photolytic degradation is provided. SAE-CD gives better effect as compared with the other cyclodextrin derivatives. The compositions under the invention reduce chiral inversion rate (S) of clopidogrel into (R)-clopidogrel.

EFFECT: compositions give substantial pharmacokinetic, pharmacodynamics and/or therapeutic advantages as compared with a tablet composition introduced orally and not containing SAE-CD.

58 cl, 18 dwg, 14 tbl, 27 ex