CLOPIDOGREL PROCESS AND INTERMEDIATE COMPOUNDS THEREFOR Russian patent published in 2009 - IPC C07D495/04 

Abstract RU 2357970 C1

FIELD: chemistry.

SUBSTANCE: invention refers to Clopidogrel process by optical separation of its racemic form with using optically active amine of formula V to make optically active form of compound of formula III or its acid-additive salt followed with methylation of compound III or its salts. The intermediate product of formula resulted from reaction of racemic form of Clopidogrel and amine V.

EFFECT: possibility to make a high-yield end product.

22 cl, 12 ex

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RU 2 357 970 C1

Authors

Kim Eun Sook

Kim Khee Cheol

Kvon Bo Sung

Jun Sangmin

Ko Mi Joung

Kim Cheol Kiung

Sukh Kvee Khiun

Dates

2009-06-10Published

2005-11-28Filed