FIELD: medicine; rheumatology.
SUBSTANCE: preparation includes 0.1-3.0 mass % of methotrexate within phospholipid nanoparticles. Nanoparticles consist of phospholipids, glycyrrhizic acid or its salt and adjuvants. The total content of phospholipids and glycyrrhizic acid and its salts is 2-80 mass %. Mass ratio of phospholipids and glycyrrhizic acid or its salts is no more 4:1. Invention also concerns method of rheumatic diseases treatment by means of specified preparation.
EFFECT: decrease in preparation by-effects and maintenance of its therapeutic potential for rheumatic diseases treatment.
4 cl, 3 dwg, 1 tbl, 1 ex
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Authors
Dates
2008-08-10—Published
2006-04-26—Filed