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2 330 849

(13)

(51)

IPC

C07D401/06(2006-01-01)

C07D217/06(2006-01-01)

C07D403/06(2006-01-01)

C07D471/08(2006-01-01)

C07D401/04(2006-01-01)

C07D471/04(2006-01-01)

C07D471/06(2006-01-01)

C07D209/44(2006-01-01)

C07D209/18(2006-01-01)

C07D223/18(2006-01-01)

C07D401/12(2006-01-01)

C07D405/12(2006-01-01)

C07D409/12(2006-01-01)

C07C237/12(2006-01-01)

C07C237/14(2006-01-01)

A61K31/5513(2006-01-01)

A61K31/4704(2006-01-01)

A61K31/4725(2006-01-01)

A61K31/473(2006-01-01)

A61K31/381(2006-01-01)

A61K31/44(2006-01-01)

A61K31/357(2006-01-01)

A61K31/4035(2006-01-01)

A61K31/404(2006-01-01)

A61P25/28(2006-01-01)

(21) (22)

Application

2005127666/04, 2004-01-27

(24)

Start date

2004-01-27

(22)

Actual filing date

2004-01-27

(45)

Published

2008-08-10

(72)

Inventor

Gallej GuidoGergle AnnikJakobzen Khel'MutKitas Ehrik ArgiriosPeters Jens-Uve

(73)

Holder

F.Khoffmann-Lja Rosh Ag

MALONAMIDE DERIVATIVES AS γ-SECRETASE INHIBITORS Russian patent published in 2008 - IPC C07D401/06 C07D217/06 C07D403/06 C07D471/08 C07D401/04 C07D471/04 C07D471/06 C07D209/44 C07D209/18 C07D223/18 C07D401/12 C07D405/12 C07D409/12 C07C237/12 C07C237/14 A61K31/5513 A61K31/4704 A61K31/4725 A61K31/473 A61K31/381 A61K31/44 A61K31/357 A61K31/4035 A61K31/404 A61P25/28

Abstract RU 2330849 C2

FIELD: chemistry.

SUBSTANCE: invention concerns malonamide derivatives of the formulae (IA) or (IB) , and pharmaceutically acceptable acid additive salts of them, where R¹, R¹',(R²)_1,2,3, R³, R⁴, R¹⁴, L, and are such as described in this invention. Also the invention concerns a medicine with inhibition effect on γ-secretase, which can be applied in treatment of Alzheimer's disease.

EFFECT: obtaining new malonamide derivatives with beneficial biological properties.

17 cl, 188 ex

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RU 2 330 849 C2

Authors

Gallej Guido

Gergle Annik

Jakobzen Khel'Mut

Kitas Ehrik Argirios

Peters Jens-Uve

Dates

2008-08-10—Published

2004-01-27—Filed