AMINOSUBSTITUTED DIARYL [a, d] CYCLOHEPTANE ANALOGUES AS MUSCARINIC AGONISTS AND METHOD OF TREATING PSYCHONEUROLOGICAL DISORDERS Russian patent published in 2010 - IPC C07D403/04 A61K31/551 A61P25/28 

FIELD: chemistry.

SUBSTANCE: present invention relates to a compound having the structural formula I , or its pharmaceutically acceptable salt, ester or amide, where A has the structure , where each bond in A, represented by a dotted and a solid line, represents a carbon-carbon single bond; each of a, b and c is a carbon atom; each of e, f, g and h is a carbon atom; X is nitrogen; X' is C; L is absent; each n equals 1; Y is nitrogen; W is nitrogen; R₁ is hydrogen; each of R₂, R₃ and R₄ is a hydrogen atom; each of R₆, R₈ and R₉ is a hydrogen atom; R₅ is selected from a group consisting of halogen, C_1-6alkyl, optionally substituted with a hydroxy group, and C_1-6alkoxy; R₇ is selected from a group consisting of halogen, C_1-6alkyl and perhalogenalkyl; Z is selected from a group consisting of NR₁₁, oxygen and CH₂; R₁₁ is hydrogen; and each bond in formula I, represented by a dotted and a solid line, is a carbon-carbon double bond. The invention also relates to a method for synthesis of a formula V compound, a pharmaceutical composition based on a formula I compound, methods of treating psychoneurological disorders, a pharmaceutical composition containing a formula I compound and a psychoneurological agent.

EFFECT: obtaining novel compounds useful for modulating muscarine receptor activity.

37 cl, 1 tbl, 141 ex