FIELD: chemistry.
SUBSTANCE: invention concerns a new 1-(3,4-diethoxyphenyl)-2,3,5,6-tetrahydro-(3,4-diethoxybenzo)[g]quinoxalino[2,3-b]indolisine hudrochloride of the formula: 
which exhibits direct anticoagulation effect and credibly prolongs coagulation time for nitrate blood and coagulability change rate in the concentration of 1 mg/ml at 36.5%. LD50 for intraperitoneal introduction to white mice comprised 355.0 (310.0÷410.0) mg/kg. T"пл" 160-161°C (isopropanol).
EFFECT: obtaining of the claimed compound.
1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| 2,2-DIMETHYL-4-(4,6-DIMETHYL-2-PYRIDON-3-YL)-1,2-DIHYDROBENZO[f]ISOQUINOLINE HYDROCHLORIDE ELECTING DIRECT ANTICOAGULANT EFFECT | 2006 |
|
RU2320654C1 |
| 1,4,5,6-TETRAHYDRO-6-OXO-5-(2-PIPERAZINOETHYL)-4-PHENYL-3-(4-CHLOROPHENYL)PYRROLO[3.4-C]PYRAZOLE DIHYDROCHLORIDE ELICITING HYPOTENSIVE AND ANTI-COAGULANT ACTIVITY | 2006 |
|
RU2320661C2 |
| N-ISOPROPYLAMIDE 2-(6,7-DIMETHOXY-3-SPIRO-CYCLOPENTYL-3,4-DIHYDROISOQUINOLYL-1)-ETHANOIC ACID HYDROCHLORIDE, WHICH POSSESSES HYPERTENSIVE ACTIVITY | 2010 |
|
RU2491277C2 |
| 2-(4'CHLOROPHENOXY)-N,N-DIETHYLETHANAMINE HYDROCHLORIDE MEDIUM WITH DIRECT ANTICOAGULATION EFFECT | 2007 |
|
RU2348610C2 |
| THIAZOLINE AMMONIUM 2-HYDROXY-4-OXO-4-(4-CHLOROPHENYL)-2-BUTENOATE, HAVING ANTICOAGULATION ACTIVITY | 2009 |
|
RU2461550C2 |
| AMIDE OF 2-(3-METHYL-6-METHOXY-7-ETHOXY-3,4-DIHYDROISOQUINOLYL-1)-ETHANOIC ACID HYDROCHLORIDE, HAVING ANTHELMINTIC ACTIVITY | 2013 |
|
RU2543374C2 |
| 2-HYDROXY-4-OXO-4-(4'-CHLOROPHENYL)-BUT-2-ENOAT 4-METHYL-2-PYRIDYLAMMONIUM THAT HAS A DIRECT ANTICOAGULANT ACTION | 2015 |
|
RU2649140C2 |
| N-BENZYLAMIDE 2-(3-METHYL-6-METHOXY-7-ETHOXY-3,4-DIHYDROISOQUINOLYL-1)-ETHANIC ACID HYDROCHLORIDE, DEMONSTRATING INSECTICIDAL ACTIVITY | 2012 |
|
RU2529504C2 |
| 4-ACETYL-3-HYDROXY-1-(2-HYDROXYETHYLAMINOETHYL)-5-PHENYL-3-PYRROLIN-2-ONE ELICITING ANTI-COAGULANT ACTIVITY | 2005 |
|
RU2312660C2 |
| MALEIC ACID 3-METHYL-2-PYRIDYLAMIDE ELICITING DIRECT ANTICOAGULANT EFFECT | 2005 |
|
RU2294199C2 |
