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IPC

C07D487/04(2006-01-01)

A61K31/496(2006-01-01)

A61P7/02(2006-01-01)

A61P9/12(2006-01-01)

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Application

2006108186/04, 2006-03-15

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Start date

2006-03-15

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Actual filing date

2006-03-15

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Published

2008-03-27

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Inventor

Gejn Vladimir LeonidovichSyropjatov Boris JakovlevichKasimova Natal'Ja NurislamovnaDozmorova Natal'Ja ViktorovnaEgorova Anastasija OlegovnaIsmajlova Natal'Ja Gennad'Evna

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennaja Farmatsevticheskaja Akademija Federal'Nogo Agentstva Po Zdravookhraneniju I Sotsial'Nomu Razvitiju Rossijskoj Federatsii" Vpo Pgfa Roszdrava)

1,4,5,6-TETRAHYDRO-6-OXO-5-(2-PIPERAZINOETHYL)-4-PHENYL-3-(4-CHLOROPHENYL)PYRROLO[3.4-C]PYRAZOLE DIHYDROCHLORIDE ELICITING HYPOTENSIVE AND ANTI-COAGULANT ACTIVITY Russian patent published in 2008 - IPC C07D487/04 A61K31/496 A61P7/02 A61P9/12

Abstract RU 2320661 C2

FIELD: organic chemistry, chemical technology, medicine.

SUBSTANCE: invention relates to 1,4,5,6-tetrahydro-6-oxo-5-(2-piperazinoethyl)-4-phenyl-3-(4-chlorophenyl)pyrrolo[3.4]pyrazole dihydrochloride of the formula (I): . This compound is synthesized by interaction of 1-(2-piperazinoethyl)-5-phenyl-4-(4-chlorobenzoyl)-3-hydroxy-3-pyrrolin-2-one dihydrochloride with hydrazine hydrate. Synthesized compound can be used in medicine as agent decreasing arterial blood pressure and blood coagulation. Invention provides synthesis of a novel compound not described early that possesses hypotensive and anti-coagulant effect simultaneously.

EFFECT: valuable medicinal properties of compound.

3 tbl, 1 ex

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RU 2 320 661 C2

Authors

Gejn Vladimir Leonidovich

Syropjatov Boris Jakovlevich

Kasimova Natal'Ja Nurislamovna

Dozmorova Natal'Ja Viktorovna

Egorova Anastasija Olegovna

Ismajlova Natal'Ja Gennad'Evna

Dates

2008-03-27—Published

2006-03-15—Filed