HYDROXY-TETRAHYDRO-NAPHTHALENYL-UREA DERIVATIVES Russian patent published in 2008 - IPC C07C275/28 C07C275/30 C07C275/32 C07C275/34 C07C275/40 C07C275/42 A61K31/17 A61P13/00 A61P29/00 

FIELD: chemistry, pharmaceuticals.

SUBSTANCE: invention pertains to derivatives of tetrahydronaphthalene and their salts, which have antagonistic properties towards the vanilloid receptor, to their use and medicinal preparation based on them. The compounds can be used for curing and preventing diseases, related to the activity of VR1, particularly for treating acute uroclepsia, hyperactive urinary bladder, chronic pain etc. In general formula (I) X represents an alkyl with 1-6 carbon atoms, or , Y represents a single bond, or , R¹, R² and R³ independently represent hydrogen, halogen, hydroxyq, nitro, carboxyl, amino, (C_1-6alkyl)amino, di(C_1-6alkyl)amino, (C_3-8cycloalkyl)amino, (C_1-6alkoxy)carbonyl, sulfonamide, C_1-6alkyl, optionally substituted with a cyano group or mono-, di-, or tri-halogen, C_1-6alkoxy group, optionally substituted with a halogen or C_1-6alkyl group, or (C_1-6alkyl)thio-group, optionally substituted mono-, di- or tri-halogen; R⁴, R⁵, R⁶ and R⁷ independently represent hydrogen, alkyl with 1-6 carbon atoms or phenyl; Z¹ represents hydrogen or alkyl with 1-6 carbon atoms; and Z² represents hydrogen, halogen or alkyl with 1-6 carbon atoms.

EFFECT: obtaining tetrahydronaphthalene derivatives and its salts, with antagonistic properties towards the vanilloid receptor.

10 cl, 3 tbl, 123 ex