PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES Russian patent published in 2008 - IPC C07C317/22 C07D213/65 C07D215/227 C07D215/26 A61K31/145 A61K31/44 A61K31/4704 A61P11/00 

FIELD: chemistry.

SUBSTANCE: invention relates to the new phenethanolamine derivatives having selective stimulant action at β₂-adrenoreceptors and can be used for the treatment of respiratory diseases. In formula (I) m is an integer from 2 to 8, n is an integer from 3 to 11 with the proviso that the sum total of m and n is from 5 to 19, R¹ represents SOR⁶ or SO₂R⁶, where R⁶ represents a C_3-7cycloalkyl group or a C_3-7cycloalkelene group, R² and R³ are independently derived from hydrogen and C_1-6alkyl, each of R⁴ and R⁵ represents hydrogen, Ar represents a group selected from (a) and (b) where R⁸ represents hydrogen, halogen, -(CH₂)_qOR¹¹, -NR¹¹C(O)R¹² or -NR¹¹SO₂R¹², and R⁷ represents hydrogen, or R⁸ represents -NR¹¹C(O)R¹² and forms with R⁷ 5- or 6-membered heterocyclic ring, R⁹ represents -OR¹¹, R¹⁰ represents hydrogen, each of R¹¹ and R¹² independently represents hydrogen or C_1-4alky, q is zero or an integer from 1 to 4. The invention also relates to the methods of compounds production and their application in pharmaceuticals production.

EFFECT: production of the new phenethanolamine derivatives having a selective stimulant action can be used for the treatment of respiratory disease.

16 cl, 5 dwg, 18 ex