4-(2-AMINO-1-HYDROXYETHYL)PHENOL DERIVATIVES AS β2 ADRENERGIC RECEPTOR AGONISTS Russian patent published in 2012 - IPC C07C217/10 C07C217/26 C07C233/43 C07C275/32 C07D215/26 C07D233/74 A61K31/135 A61K31/4166 A61K31/4704 A61P11/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula (I), as well as pharmaceutically acceptable salts or stereoisomers thereof, having activity on the β2 adrenergic receptor. In formula R¹ denotes a group selected from -CH₂OH, -NHC(O)H, and R² denotes a hydrogen atom; or R¹ together with R² form a -NH-C(O)-CH=CH- group, where the nitrogen atom is bonded with a carbon atom of the phenyl ring containing R¹, and the carbon atom is bonded with a carbon atom of the phenyl ring containing R²; R³ is selected from a group containing hydrogen and halogen atoms, or denotes a group selected from -NH-CO-NH₂, a hydantoic group, C₁-C₄alkyl and C₁-C₄alkoxy group; R⁴ is selected from a group comprising hydrogen atoms, halogen atoms and C₁-C₄alkyl groups; n, p and q are independently equal to 0, 1, 2, 3 or 4; m and s are independently equal to 0, 1, 2 or 3; r equals 0, 1 or 2; under the condition that at least one of m and r is not equal to, the sum n+m+p+q+r+s equals 7, 8, 9, 10, 11, 12 or 13, the sum q+r+s equals 2, 3, 4, 5 or 6. The invention also relates to a pharmaceutical composition and treatment and modulation methods.

EFFECT: high efficiency of the composition.

20 cl, 18 ex