SPIRO(5,5)UNDECANE DERIVATIVES Russian patent published in 2014 - IPC C07D209/86 C07D471/04 A61K31/437 A61K31/403 A61P25/04 

FIELD: chemistry.

SUBSTANCE: invention relates to field of organic chemistry, namely to compound of general formula (1), where A₁ represents -N= or -CR₇=, A₂ represents -N= or -CR₈, A₃ represents -N= or -CR9=, A₄ represents -N= or -CR₁₀=; on condition that not more than one of residues A₁, A₂, A₃ and A₄ represents -N=; Y₁, Y₁′, Y₂, Y₂′, Y₃, Y₃′, Y₄ and Y₄' in each case independently on each other represent -H or -C_1-8-alkyl; W represents -NR₄-, where R₄ represents -H or -C_1-8-alkyl; R₁, R₂ and R₃ independently on each other in each case represent R₀, where R₀ represents non-substituted or monosubstituted -C_1-8-alkyl; non-substituted or monosubstituted -phenyl; non-substituted or monosubstituted - heteroaryl or non-substituted or monosubstituted -C_1-8-alkylphenyl; or R₁ and R₂ together represent -(CH₂)_3-6-; R₅, R₅' R₆, R₆' R₇ R₈, R₉, R₁₀, R₁₈ and R₁₉ in each case independently on each other are selected from group, including -H, -F, -Cl, -Br, -I and -R₀; where "heteroaryl" represents 5-membered cyclic aromatic residue, which contains 1 heteroatom, where heteroatom represents sulphur; where "alkyl" in each case represents branched or non-branched, saturated, non-substituted or monosubstituted aliphatic hydrocarbon residue; where with respect to residues "phenyl", "-C_1-8-alkyl", "heteroaryl" and "-C_1-8-alkylphenyl" "monosubstituted" means monosubstitution of one hydrogen atom with substituents, selected from group, including -F, -Cl, -Br, -I or -OH, in form of single stereoisomer or their mixture, free compound and/or its physiologically compatible salts.

EFFECT: obtained is novel compound and medication based on thereof, which can be applied in medicine for pain treatment.

9 cl, 15 ex