METHOD OF NIMESULIDE QUANTITATION Russian patent published in 2008 - IPC G01N33/15 G01N21/33 A61K31/18 

FIELD: medicine.

SUBSTANCE: invention refers to medicine and can be used in analytical laboratories for standardisation and quality assurance of medical products. The method involves preparing solutions of defined substance and the standard reference solution. Clear water and 0.1 M sodium hydroxide solution are used as a dissolvent for preparation of a defined solution, nickel chloride being used as the standard reference solution. The method further includes measuring optical density of a defined solution and reference nickel chloride solution using spectrophotometer; calculating results from the formula and entering recalculation factor therein.

EFFECT: increased sensitivity of the analysis and reproducibility of results; reduced toxicity, labour input, and analytical error.

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