FIELD: chemistry.
SUBSTANCE: invention relates to improved method of obtaining 4-R-substituted anthracyclines of formula (I) 
, and their corresponding salts from 4-demethyldaunorubicin. Steps of treating 4-demethyldaunorubicin with a sulfonylating agent to form 4-demethyl-4-sulfonyl-R3-daunorubicin. 4-Demethyl-4-R3-sulfonyl-daunorubicin are performed, then it is processed with reducing agent in the presence of a transition metal catalyst in a temperature range from 30°C to 100°C in polar aprotic solvent in an inert atmosphere. Protected 4-demethoxy-4-R-daunomycin then undergoes hydrolysis in a basic solution to form the 4-R-substituted anthracyclines. Application of novel method makes it possible to avoid stage of forming stereospecific glycoside bond between aglycone and aminoglycoside. The method also increases the yield of final product up to 30-40%.
EFFECT: elaboration of efficient method of obtaining 4-R-substituted demethyldaunorubicin.
13 cl, 10 ex
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