EXTRUSION OF HOT LIQUID OF MULTIPLE PARTICLES WITH MODIFIED RELEASE Russian patent published in 2013 - IPC A61K9/16 A61K9/20 A61K9/26 A61K47/34 A61K47/38

Abstract RU 2483713 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical composition with controlled release. Claimed composition includes one or more multiple particles with modified release with dimensions 50-800 mcm, which have effective quantity of one or more therapeutic compounds. Said multiple particles possess known profile of medication release and are subjected to thermal processing into extrudate in thermoplastic polymer matrix or lipid material. Invention also relates to method of obtaining pharmaceutical composition with controlled release and to pharmaceutical hard dosage form, which includes said composition.

EFFECT: invention ensures preservation of predominance of known profile of release of multiple particle medication when it is released from thermoplastic polymer matrix or lipid material.

35 cl, 6 dwg, 12 tbl, 10 ex

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RU 2 483 713 C2

Authors

Makginiti Dzhejms V.

Shilling Sandra

Dates

2013-06-10—Published

2009-08-20—Filed