SUBSTITUTED INDOLES AND PHARMACEUTICAL COMPOSITION, POSSESSING AGONISTIC ACTIVITY WITH RESPECT TO ALFA- 1A/L ADRENORECERPTOR Russian patent published in 2008 - IPC C07D403/06 C07D403/14 C07D495/04 A61K31/475 A61K31/4178 A61P13/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel substituted indoles of general formula , where: X stands for -S(O)_n-, -C(O)-; A stands for C₁-C₆alkyl, -(CH₂)_p-NR^aR^b; R¹, R², R³ and R⁴ each is independently selected from group including H, halogen, halogen(C₁-C₆)alkyl, C₁-C₆alkyl, C₁-C₆alkoxy, C₁-C₆alkylthio, C₁-C₆alkylsulfinyl, C₁-C₆alkylsulfonyl, NO₂, -NR^aR^b, phenyl, benzyl and benzyloxy, said phenyl cycles are optionally substituted with substituent, selected from group including C₁-C₆alkyl, halogen, NO₂, halogen(C₁-C₆)alkyl, C₁-C₆alkoxy; R⁵ stands for H, C₁-C₆alkyl, C₁-C₆alkoxy, C₁-C₆alkoxy C₁-C₆alkyl, C₁-C₆alkylthio, C₁-C₆alkylsulfinyl, C₁-C₆alkylsulfonyl, hydroxyl-(C₁-C₆)alkyl, hydroxy(C₁-C₆)alkylamino, halogen, halogen(C₁-C₆)alkyl-NR^aR^b, -NR^c-( C₁-C₆)alkylene-NR^aR^b, or R⁵ and A together form radical C₂-C₃alkylene; R⁶ stands for H, C₁-C₆alkyl; R' and R" each independently stand for H, C₁-C₆alkyl; R^a, R^b and R^c each is independently chosen from group including H, C₁-C₆alkyl, hydroxy(C₁-C₆)alkyl, C₂-C₆alkenyl, C₃-C₆cycloalkyl-(C₁-C₆)alkyl, or R^a and R^b together with nitrogen atom, to which they are attached, form 5-7 member non-aromatic heterocyclic cycle, optionally containing in cycle O as additional heteroatom; m is equal 1 or 2; n is equal 0, 1 or 2 under condition that, if n is equal 0, R⁵ does not stand for NR^aR^b, and p is equal 0, 1 or 2; or their pharmaceutically acceptable salts.

EFFECT: obtaining compounds possessing agonistic activity which allows using them in pharmaceutical composition.

24 cl, 2 tbl, 22 ex