INDAZOL DERIVATIVES AS CRF ANTAGONISTS Russian patent published in 2008 - IPC C07D231/56 

FIELD: chemistry.

SUBSTANCE: indazol receptors of formula I demonstrate antagonistic activity with respect to CRF receptor, which can be used in medicine. , in which R represents phenyl or pyridinyl, optionally substituted with alkyl, alkoxygroup or halogen; R1 represents -NR^aR^b, -CR^cR^dR^e, CO₂R^a or -C(O)NR^aR^b; Ra and R^b are selected from hydrogen, alkyl-, cycloalkyl-, aryl- or heterocyclyl-containing groups or together with nitrogen atom form heterocycle; R^c represents hydrogen, hydroxyl-group, alkoxy-group or -NR^a R^b; Rd and Re are selected from hydrogen, alkyl-, aryl- or heterocyclyl-containing groups or together with carbon atom form cycloalkyl or heterocycle; Rc and Rd together form group =CRR`, where R represents heteroalkyl, halogenalkyl, alkyl, or hydrogen, and R` represents alkyl-, cycloalkyl-, aryl- or heterocyclyl-containing groups; R^a′′′ and R^b′′′ are selected from hydrogen, alkyl-, cycloalkyl-, aryl- or heteroaryl-containing groups or together with nitrogen atom form heterocycle.

EFFECT: obtaining novel biologically active compounds.

2 cl, 12 ex, 2 tbl