Show metadata Hide metadata

(19)

(11)

2 337 918

(13)

(51)

IPC

C07J5/00(2006-01-01)

C12P33/02(2006-01-01)

(21) (22)

Application

2006120564/04, 2006-06-14

(24)

Start date

2006-06-14

(22)

Actual filing date

2006-06-14

(45)

Published

2008-11-10

(72)

Inventor

Savinova Tat'Jana StepanovnaKazantsev Aleksej Vital'EvichLukashev Nikolaj VadimovichArinbasarova Anna Jur'EvnaStepanov Anatolij IvanovichSkrjabin Georgij Andreevich

(73)

Holder

Ambiotek, Ink

METHOD OF OBTAINING 6α-METHYLHYDROCORTISONE OR ITS 11β-ALKANOYLOXY-DERIVATIVES (VERSIONS), METHOD OF OBTAINING 6α-METHYLPREDNISOLONE OR ITS 11β-ALKANOYLOXY-DERIVATIVES USING OBTAINED 6α-METHYLHYDROCORTISONE OR ITS 11β-ALKANOYLOXY-DERIVATIVES Russian patent published in 2008 - IPC C07J5/00 C12P33/02

Abstract RU 2337918 C9

FIELD: chemistry.

SUBSTANCE: 6α-methylhydrocortisone and its 11β-alkanoyloxy-derivatives are obtained by method that includes preliminary protection of 11β,- 17α- and 21-hydroxy groups of hydrocortisone or its 21-acyloxy-derivative in step-by-step way with formation of 17α,20;20,21-bismethylenedioxy-derivative (BMDO-protection of dioxyacetone side chain) and further sterification of 11β-hydroxy group, methylenisation of C₆ position, reduction of 6-methylene group into 6α-methyl one. 6α-methylprednisolone or its 11β-alkanoyloxy-derivatives are obtained by reaction of 1,2-dehydrogenation of 6α-methylhydrocortisone and its 11β-alkanoyloxy-derivatives by microbiological transformation by means of microbial cells. EFFECT: obtaining of the above listed derivatives.

17 cl, 23 ex.

Similar patents RU2337918C9

Title	Year	Author	Number
METHOD FOR PREPARING 6α-METHYLHYDROCORTISONE	2006	Lukashev Nikolaj Vadimovich Kazantsev Aleksej Vital'Evich Savinova Tat'Jana Stepanovna Arinbasarova Anna Jur'Evna	RU2297423C1
METHOD OF PREPARATION 6α-METHYLHYDROCORTISONE OR ESTERS THEREOF FROM HYDROCORTISONE 21-ACETATE	2017	Savinova Tatyana Stepanovna Kazantsev Aleksej Vitalevich Lukashev Nikolaj Vadimovich	RU2663484C1
METHOD FOR OBTAINING 6-DEHYDRO-6-METHYLHYDROCORTISONE OR ESTER THEREOF FROM HYDROCORTISONE 21-ACETATE	2017	Savinova Tatyana Stepanovna Kazantsev Aleksej Vitalevich Lukashev Nikolaj Vadimovich	RU2663893C1
METHOD FOR PRODUCING 6-METHYLENEHYDROCORTISONE OR ESTERS THEREOF FROM HYDROCORTISONE 21-ACETATE	2017	Savinova Tatyana Stepanovna Kazantsev Aleksej Vitalevich Lukashev Nikolaj Vadimovich	RU2664101C1
METHOD OF PREPARING 6-(N-METHYL-N-PHENYL)AMINOMETHYL-HYDROCORTISONE ESTERS THEREOF FROM HYDROCORTISONE 21-ACETATE	2017	Savinova Tatyana Stepanovna Kazantsev Aleksej Vitalevich Lukashev Nikolaj Vadimovich	RU2663483C1
METHOD OF OBTAINING 11BETA, 17 ALPHA, 21-TRIHYDROXY-16ALPHA-METHYL-9ALPHA-FLUOROPREGNA-1,4-DIENE-3,20-DIONE (DEXAMETHAZONE) FROM PHYTOSTEROL	2013	Kazantsev Aleksej Vital'Evich Alexey Vitalievich) Savinova Tat'Jana Stepanovna Tatyana Stepanovna) Lukashev Nikolaj Vadimovich Nikolay Vadimovich) Dovbnja Dmitrij Vladimirovich Dmitry Vladimirovich) Khomutov Sergej Mikhajlovich Sergei Mikhailovich) Sukhodol'Skaja Galina Viktorovna Galina Viktorovna) Shutov Andrej Anatol'Evich Andrei Anatolievich) Fokina Viktorija Valer'Evna Vistoria Valerievna) Nikolaeva Vera Maksimovna Vera Maximovna) Donova Marina Viktorovna Marina Viktorovna) Egorova Ol'Ga Valer'Evna Olga Valerievna) Surovtsev Viktor Vasil'Evich Viktor Vasilievich)	RU2532902C1
MICROBIOLOGICAL METHOD OF PRODUCING 1,2-DEHYDROGENATED DERIVATIVES OF Δ-3-KETO-STEROIDS OF ANDROSTANE FAMILY IN AQUEUS ORGANIC MEDIA	2010	Sukhodol'Skaja Galina Viktorovna Savinova Tat'Jana Stepanovna Fokina Viktorija Valer'Evna Shutov Andrej Anatol'Evich Nikolaeva Vera Maksimovna Lukashev Nikolaj Vadimovich Surovtsev Viktor Vasil'Evich Donova Marina Viktorovna	RU2447154C1
METHOD OF PRODUCING 6-METHYLENEANDROST-4-ENE-3,17-DIONE FROM ANDROST-4-ENE-3,17-DIONE, METHOD OF PRODUCING 6-METHYLENEANDROST-1,4-DIENE-3,17-DIONE (EXEMESTANE) USING OBTAINED 6-METHYLENEANDROST-4-ENE-3,17-DIONE	2010	Savinova Tat'Jana Stepanovna Lukashev Nikolaj Vadimovich Latyshev Gennadij Vladimirovich Sukhodol'Skaja Galina Viktorovna Donova Marina Viktorovna Fokina Viktorija Valer'Evna Shutov Andrej Anatol'Evich Nikolaeva Vera Maksimovna Surovtsev Viktor Vasil'Evich	RU2425052C1
METHOD OF PRODUCING 3β-ACETOXY-17α-HYDROPEROXY-16α-METHYLPREGNANES FROM Δ-20-KETOSTEROIDS AND METHOD OF PRODUCING 3β-ACETOXY-17α-HYDROXY-16α-METHYLPREGNANES USING 3β-ACETOXY-17α-HYDROPEROXY-16α-METHYLPREGNANES	2009	Savinova Tat'Jana Stepanovna Lukashev Nikolaj Vadimovich Beletskaja Irina Petrovna	RU2418805C1
DERIVATIVES OF ANDROSTENE, PHARMACEUTICAL COMPOSITION	1997	Bodor Nikolas S.	RU2194053C2

RU 2 337 918 C9

Authors

Savinova Tat'Jana Stepanovna

Kazantsev Aleksej Vital'Evich

Lukashev Nikolaj Vadimovich

Arinbasarova Anna Jur'Evna

Stepanov Anatolij Ivanovich

Skrjabin Georgij Andreevich

Dates

2008-11-10—Published

2006-06-14—Filed